Brentford faces significant midfield challenges. Key midfielders, Carvalho and Milan, are out for the season due to cruciate ligament injuries, impacting the team's midfield rotation. Additionally, key forward Dango Ouattara and substitute midfielder Frank Onyeka will miss the match and subsequent league games due to their participation in the Africa Cup of Nations. Tottenham Hotspur's situation is also dire, especially in midfield. The absence of creative players like Maddison and Kulusevski directly affects the team's attacking organisation and wing play. Furthermore, the absence of Sarr and Bissouma, who are also at the Africa Cup of Nations, exacerbates the midfield shortage, significantly reducing the efficiency of the team's passing system. Tottenham Hotspur holds a considerable psychological advantage. In their last ten encounters across all competitions, Tottenham Hotspur has secured six wins, three draws, and only one loss. Brentford has lost their last four matches against Tottenham Hotspur, highlighting a clear psychological disadvantage. In their recent five meetings, Tottenham Hotspur has performed better. They won 2-0 at home against Brentford in the 15th round of the Premier League in December 2025 and 2-0 again in a league match in February 2025. Tottenham Hotspur also won in September 2024 and February 2024. Brentford's last victory over Tottenham Hotspur dates back to May 2023, when they won 3-1 at home. The betting suggestion is Brentford -0.25.