The Championship clash between Southampton and Millwall presents an intriguing matchup, with a history that suggests a tight contest but current form leaning heavily towards the home side. Southampton, with their promotion aspirations, are clear favorites, but Millwall's fighting spirit cannot be easily dismissed. Looking at the head-to-head record, the data reveals a mixed bag. The recent matches show a slight Southampton advantage, but Millwall has proven they can secure a result, as demonstrated in their recent 3-2 victory against Southampton. This historical context suggests that Millwall is capable of causing an upset, but their away form and Southampton’s current positioning in the league heavily favor the home side in this encounter. The injury data suggests minor concerns on both sides, with Southampton having more key players out. However, the depth of the Southampton squad should be enough to mitigate the impact of the absences. Millwall's injury list further weakens their chances against a team striving for promotion. The bookmakers' odds reflect the expected outcome, with a clear favorite being Southampton. The Asian Handicap of -0.75 for Southampton implies the expectation of a comfortable victory. The odds also suggest a high probability of goals, reflected in the Over/Under line of 2.75. Considering the historical data, team form, and injury situation, my prediction leans towards a Southampton victory. The Saints should be able to navigate past a potentially resilient Millwall side. I am predicting a home win with a slight margin, reflected in the Asian Handicap prediction. Given the attacking potential of both teams, the Over/Under on goals seems very likely. Therefore, Southampton should secure the win, in a match with over 2.75 goals scored.