The upcoming clash between Southampton and Millwall promises to be a compelling encounter in the England Championship. Based on the available data, including head-to-head records, league standings, and odds, I'm leaning towards a Southampton victory. Southampton's superior goal difference and slightly better attacking record suggest they can edge out Millwall. The odds also reflect this, with Southampton being the clear favorites. Looking at the head-to-head history, the results are mixed, but Southampton have historically performed well. Although Millwall has secured wins, Southampton have consistently found the net, which is crucial. Recent form is another key consideration. Southampton's slightly better record in recent matches indicates a potential form advantage. While Millwall can be a tough opponent, Southampton's home advantage and overall squad strength give them the edge. The Asian Handicap favors Southampton, indicating confidence in their ability to win by more than one goal. The Over/Under market suggests a high-scoring game. Given both teams' scoring abilities and defensive frailties, it's reasonable to expect multiple goals. Consequently, the prediction aligns with a Southampton win and over 2.75 goals. Considering all the factors, I predict a Southampton victory, and I believe that the match will exceed 2.75 goals.