The upcoming England Championship match between Sheffield Wednesday and Blackburn Rovers presents an intriguing betting scenario. Analyzing the provided data, a prediction can be formulated based on several key factors. The head-to-head record heavily favors Sheffield Wednesday, with a significant number of wins in their recent encounters. While the injury data shows absences on both sides, it's the match odds that ultimately inform the prediction. The Asian Handicap favors Blackburn Rovers with a +0.75 handicap, and the odds suggest a slight advantage for the away team, indicating the bookmakers expect a close game, but still favor Blackburn Rovers, and I will be following the bookmakers here. The over/under market is set at 2.25 goals, implying an expectation of a moderately high-scoring game. The win/draw/loss market also reflects this, with Blackburn Rovers being assigned a lower odd, and therefore being considered more likely to win. Considering all the data, the prediction leans towards an away win for Blackburn Rovers with Asian Handicap favoring the away team, the bookmakers setting the odds slightly in favor of an away win further reinforces this prediction. The over/under market also suggests a reasonable probability of the game exceeding 2.25 goals, which may be a result of the perceived attacking abilities of both teams. The historical head-to-head results support Sheffield Wednesday, but the match odds reveal Blackburn Rovers as the favorite. It is important to acknowledge the inherent uncertainty in sports, and these predictions are based on the available data at the time of analysis. Injury situations can also significantly impact the team's performance, but the information about which key players are absent is not available. Nevertheless, the statistical probabilities point towards an away win for Blackburn Rovers with a relatively high-scoring match. Therefore, a bet on Blackburn Rovers with a +0.75 Asian Handicap and Over 2.25 goals seems to be a reasonable strategy. As a responsible analyst, all betting decisions must be made with the understanding that these are predictions, and outcomes can always differ.