AS Roma are heavily favoured in their upcoming Serie A match against Genoa. Historical head-to-head data strongly supports this, with Roma enjoying a clear advantage in recent encounters. The provided odds reflect this, with a low home win payout suggesting high confidence in a Roma victory. The Asian Handicap of -0.75 for Roma indicates a prediction of a comfortable win, and considering Roma's offensive capabilities, we expect them to score at least two goals. Injury news shows both teams are dealing with absences, but this is unlikely to drastically impact the overall result. Given Roma's consistent performance and superior squad, we anticipate a home win with goals exceeding the Over/Under line of 2.25.