As a Senior Football Tactical Analyst, I've thoroughly examined the upcoming Serie A match between AS Roma and Genoa, considering various factors to formulate a well-informed prediction. Firstly, the league standings strongly favour AS Roma. Currently positioned 5th, they've demonstrated a stronger overall performance compared to Genoa, who are languishing in 17th. Roma's superior goal difference (+7 vs. Genoa's -8) further highlights their attacking prowess and defensive solidity. The provided match odds also reflect this, with Roma being the clear favourites. Looking at recent form, Roma's home form, though inconsistent (1 win, 1 loss in their last two home league matches), is still generally better than Genoa's away form. Genoa has struggled on the road, losing to Atalanta and Inter Milan recently. Roma's recent away win in the Europa League suggests they can perform well under pressure. Head-to-head records heavily favour AS Roma. They have a dominant record against Genoa in their recent encounters, including a 3-1 victory in their last meeting. This history suggests Roma has a tactical edge, understanding how to exploit Genoa's weaknesses. Additionally, Roma's recent form against teams like Napoli indicates their ability to compete against quality opposition. Considering the injury reports, while both teams have injury concerns, the potential impact seems relatively balanced. Therefore, it is less likely to affect the match's outcome. Based on these observations, my prediction is that AS Roma will win this match. I am also leaning towards the Under 2.25 goals market, given Roma’s recent goal scoring form and Genoa's relatively tight defensive approach away from home. The Asian Handicap of -0.75 for Roma aligns with expectations of a comfortable victory for the home side.